can you shoot crack with cranberry juice

Nevertheless caution would be advised when administering cranberry with drugs metabolized by CYP2C9, which include: Lab studies show that cranberry does inhibit CYP2C9 to some extent, but studies in humans haven't shown any significant effect. Medications metabolized by CYP3A4 include:Ĭranberry may also inhibit CYP2C9, but evidence is conflicting. Although there isn't data on whether or not cranberry interacts with all medications metabolized by this enzyme, there is still the potential for it and caution is advised administering cranberry with these medications. All lab values and liver enzymes returned to normal within 2 weeks of stopping cranberry juice.Īn animal study showed that cranberry juice inhibits the metabolism of the drug nifedipine and significantly increases total concentrations of the drug in the body, which could potentially lead to serious adverse reactions.ĬYP3A4 is one of the major metabolizing enzymes in the body. One case study reported symptoms of rhabdomyolysis, and abnormal liver function in a patient taking Lipitor (atorvastatin) in combination with cranberry juice (16 ounces daily for 2 weeks). Cranberry CYP3A4 Drug InteractionsĬranberry has several documented interactions with two drugs metabolized by CYP3A4: The labeling recommends avoiding co-administration of Allegra with citrus (which can inhibit OATP) since the drug will be significantly less effective. A classic example of this interaction is with the antihistamine Allegra (fexofenadine). Without OATP, drugs may have less of an effect. In addition, cranberry may also inhibit OATP (Organic-anion-transporting polypeptide), an important transport enzyme responsible for transporting certain drugs into cells. Inhibition of metabolizing enzymes, in most cases, will decrease how quickly drugs are metabolized, potentially increasing drug concentrations in the body, increasing the risk of side effects.

Cranberry Medication InteractionsĬranberry is thought to inhibit a various CYP metabolizing enzymes in the liver including: Below, we list some potential interactions between cranberry (and cranberry juice) with medication.

However, more data and research are needed to accurately identify exactly what cranberry interacts with and how severe the potential drug interactions are. Would the medication lose its effect or get affected in anyway if I crushed the pills and pour them into cranberry juice? AnswerĬranberry juice has the potential to interact with many different medications and is therefore generally not recommended to be administered at the same time. The thing is that chocolate pudding is not working anymore. I work in a memory care facility and we have a patient who's medication we are allowed to crush.

Can you shoot crack with cranberry juice